ITRANK 100/200 MG


Each Capsule Contains:
Itraconazole 100/200 mg

1X4X10 Rs 110

10X10 Rs 180

ITRANK 100/200 MG

Itraconazole belongs to triazole and imidazole antifungal drug. It is used by immunocompromised and non-immunocompromised patients. it interacts with the membrane phospholipids thus inhibits the endogenous respiration. It also prevents the transformation of yeast into the mycelial cells. The drug accumulates in the fungi which is responsible for its fungicidal action.

  • Blastomycosis
  • Histoplasmosis
  • Aspergillosis
  • Onychomycosis

Mechanism of action-

Itraconazole inhibits the cytochrome P450 enzymes i.e. 14 alpha demethylase which is responsible for the conversion of ergosterol into lanosterol. ergosterol here is the component of fungal cell membrane.

Pharmacokinetics-

Absorption- It is absorbed orally
Protein Binding- It is 99% bound to proteins
Metabolism- It undergoes oxidation and dealkylation
Excretion- It is excreted via urine
  • Headache
  • Dizziness
  • Drowsiness
  • Rashes
  • Nausea
  • Vomiting
  • Stomach pain
  • Contraindicated in chronic heart failure
  • Contraindicated in kidney disorders
  • Rifampin
  • Phenytoin
  • Carbamazepine
  • Phenobarbital